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產(chǎn)品關(guān)鍵詞: 香草酸-4-β-D-葡萄糖苷 6-甲氧基山奈酚 茯苓新酸B 去甲異波爾定
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Xiaoer-Feire-Kechuan (XFK) is an 11-component Chinese medicine formula to treat cough and pulmonary inflammatory. The complicated composition rendered its chemical analysis and effective-component elucidation. In this study, we combined quantitative analysis and bioactivity test to reveal the anti-inflammatory constituents of XFK. Firstly, UPLC-DAD and UHPLC/Q-Orbitrap-MS methods were established and validated to quantify 35 compounds (covering 9 out of 11 component herbs) in different XFK formulations. Parallel Reaction Monitoring mode built-in Q-Orbitrap-MS was used to improve the sensitivity and selectively. Then, anti-inflammatory activities of the 35 compounds were analyzed using in vitroCOX-2 inhibition assay. Finally, major compounds mangiferin (6), forsythosides H, I, A (8-10), and baicalin (15) (total contents varied from 38.01 to 148.12 mg/dose in different formulations) with significant activities (inhibitory rate ≥ 80%) were proposed as the anti-inflammatory constituents of XFK. The present study provided an effective strategy to discover effective constituents of multi-herb formulas.
產(chǎn)品編碼:DA0040產(chǎn)品名稱:Afrormosine英文名:AfrormosineCAS登錄...
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