狠狠综合久久久久综合网,亚州少妇无套内射激情视频,成年免费A级毛片免费看丶,欧美熟妇色ⅩXXX欧美妇

德思特生物專注于中藥(植物藥)物質(zhì)基礎(chǔ)研究以及天然化合物、中藥化學(xué)對(duì)照品實(shí)物生產(chǎn)供應(yīng)


天然藥物活性單體及中藥對(duì)照品專業(yè)生產(chǎn)供應(yīng)商


聯(lián)系方式

028-85003950

聯(lián)系方式

服務(wù)熱線:

028-8500-3950

公司傳真:028-85589956
公司郵箱:sales@tcmlmt.com
公司網(wǎng)址:usemark.cn
公司地址:四川省成都市溫江區(qū)??坡肺鞫?28號(hào)5棟


發(fā)表文獻(xiàn)展示

當(dāng)前位置:首頁關(guān)于德思特 > 發(fā)表文獻(xiàn)展示 >

European Journal of Drug Metabolism and Pharmacokinetics-14 November 2017

時(shí)間:2020-09-03   瀏覽次數(shù):  分享到:
The Influence of Compatibility of Rhubarb and Radix Scutellariae on the Pharmacokinetics of Anthraquinones and Flavonoids in Rat Plasma
期刊名:European Journal of Drug Metabolism and Pharmacokinetics
文獻(xiàn)編號(hào):DOI 10.1007/s13318-017-0444-8
文獻(xiàn)地址:https://link.springer.com/article/10.1007%2Fs13318-017-0444-8
發(fā)表日期:


Abstract

Background and Objectives

Rhubarb–Radix scutellariae is a classic herb pair, which is commonly used to clear away heat and toxin in clinic. The aim of this study was to investigate the influence of compatibility of Rhubarb and Radix scutellariae on the pharmacokinetic behaviors of anthraquinones and flavonoids in rat plasma.

Methods

Eighteen rats were randomly divided into three groups, and were orally administered Rhubarb and/or Radix scutellariae extracts. A sensitive and rapid UPLC–MS/MS method was developed and validated to determine the concentrations of baicalin, baicalein, wogonside, wogonin, rhein, and emodin in rat plasma. The concentrations of phase II conjugates of flavonoid aglycones and anthraquinone aglycones were also determined after hydrolyzing the plasma with sulfatase.

Results

Compared with administration of Radix scutellariae alone, co-administration of Rhubarb significantly decreased the first maximum plasma concentration (C max1) of baicalin, wogonside, and the phase II conjugates of baicalein, wogonin to 46.40, 61.27, 41.49, and 20.50%, respectively. The area under the plasma concentration–time curve from time zero to infinity (AUC0–∞) was significantly decreased from 82.60 ± 20.22 to 51.91 ± 7.46 μM·h for rhein and 276.83 ± 98.02 to 175.42 ± 86.82 μM·h for the phase II conjugates of wogonin after compatibility. The time to reach the first maximum plasma concentration (T max1) of anthraquinones was shortened and the second peak of anthraquinones disappeared after compatibility.

Conclusions

Compatibility of Rhubarb and Radix scutellariae can significantly affect the pharmacokinetic behaviors of characteristic constituents of the two herbs. The cause of these pharmacokinetic differences was further discussed combined with the in vivo ADME (absorption, disposition, metabolism, and excretion) processes of anthraquinones and flavonoids.

Rhein (R), emodin (E), baicalin (BG), baicalein (B), wogonside (WG), and wogonin (W) standards were purchased from Chengdu Desite Biological Technology Co., Ltd. (Sichuan, China).

熱門新聞

Afrormosine CAS:550-79-8 中藥對(duì)照品標(biāo)準(zhǔn)品

產(chǎn)品編碼:DA0040產(chǎn)品名稱:Afrormosine英文名:AfrormosineCAS登錄...

查看更多

德思特
版權(quán)所有:成都德思特生物技術(shù)有限公司 Copyright © 2016   蜀ICP備16023840號(hào)-2
公司地址:四川省成都市溫江區(qū)海科路西段128號(hào)5棟
公司電話:028-85003950

掃一掃關(guān)注德思特
   掃碼關(guān)注公眾號(hào)
松潘县| 额尔古纳市| 子长县| 中卫市| 惠州市| 漠河县| 呼和浩特市| 石柱| 曲阜市| 赤峰市| 松溪县| 鄂州市| 新乡县| 同心县|