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Molecules-23 July 2019 半齒澤蘭素

時間：2020-09-03   瀏覽次數(shù)：  分享到：
Identification of Metabolites of Eupatorin in Vivo and in Vitro Based on UHPLC-Q-TOF-MS/MS
期刊名：Molecules
文獻(xiàn)編號：DOI 10.3390/molecules24142658
文獻(xiàn)地址：https://www.mdpi.com/1420-3049/24/14/2658
發(fā)表日期：23 July 2019

Abstract
Eupatorin is the major bioactive component of Java tea (Orthosiphon stamineus), exhibiting strong anticancer and anti-inflammatory activities. However, no research on the metabolism of eupatorin has been reported to date. In the present study, ultra-high-performance liquid chromatography coupled with hybrid triple quadrupole time-of-flight mass spectrometry (UHPLC-Q-TOF-MS) combined with an efficient online data acquisition and a multiple data processing method were developed for metabolite identification in vivo (rat plasma, bile, urine and feces) and in vitro (rat liver microsomes and intestinal flora). A total of 51 metabolites in vivo, 60 metabolites in vitro were structurally characterized. The loss of CH2, CH2O, O, CO, oxidation, methylation, glucuronidation, sulfate conjugation, N-acetylation, hydrogenation, ketone formation, glycine conjugation, glutamine conjugation and glucose conjugation were the main metabolic pathways of eupatorin. This was the first identification of metabolites of eupatorin in vivo and in vitro and it will provide reference and valuable evidence for further development of new pharmaceuticals and pharmacological mechanisms.

Eupatorin (855-96-9, purity > 98.94%) was purchased from Chengdu Desite Biological Technology Co., Ltd. (Chengdu, China)

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