狠狠综合久久久久综合网,亚州少妇无套内射激情视频,成年免费A级毛片免费看丶,欧美熟妇色ⅩXXX欧美妇

鄭重說(shuō)明:

您值得信賴(lài)的中藥成分及標(biāo)準(zhǔn)合作伙伴滿(mǎn)足您研發(fā)和工業(yè)化需求

產(chǎn)品關(guān)鍵詞：香草酸-4-β-D-葡萄糖苷 6-甲氧基山奈酚茯苓新酸B 去甲異波爾定

guanyuwomen關(guān)于德思特

聯(lián)系方式

服務(wù)熱線(xiàn)：

028-8500-3950

公司傳真：	028-85589956
公司郵箱：	sales@tcmlmt.com
公司網(wǎng)址：	usemark.cn
公司地址：	四川省成都市溫江區(qū)?？坡肺鞫?28號(hào)5棟

發(fā)表文獻(xiàn)展示

當(dāng)前位置:首頁(yè)關(guān)于德思特 > 發(fā)表文獻(xiàn)展示 >

Acta Pharmaceutica Sinica B-6 May 2020 雷公藤甲素 38748-32-2

時(shí)間：2020-09-03 瀏覽次數(shù)：分享到：

Injectable thermo-responsive nano-hydrogel loading triptolide for the anti-breast cancer enhancement via localized treatment based on “two strikes” effects

期刊名：Acta Pharmaceutica Sinica B
文獻(xiàn)編號(hào)：doi.org/10.1016/j.apsb.2020.05.011
文獻(xiàn)地址：https://www.sciencedirect.com/science/article/pii/S2211383520305967?via%3Dihub
發(fā)表日期：6 May 2020

Abstract

The clinical application of triptolide (TPL) in tumor therapy has been greatly limited by its toxicity and inefficient delivery. Herein, a localized and sustained-release thermo-sensitive hydrogel was developed for the intra-tumor administration of TPL. Based on the amphiphilic structure of poly (N-isopropylacrylamide-co-acrylic acid)-g-F68 copolymer, it was able to form nano-micelles to efficiently encapsulate TPL, and then turn into a hydrogel at 37 °C. TPL@nano-gel exhibited a sustained drug release profile in vitro and a stronger anticancer effect caused by “two strikes”. The “first strike” was its enhanced cytotoxicity compared to free TPL, due to the enhanced pro-apoptosis effect observed in both MDA-MB-231 and MCF-7 cells caused by the regulation of endogenous mitochondrial pathways. Furthermore, TPL@nano-gel exhibited a “second-strike” through its anti-angiogenesis capabilities mediated through VEGFR-2 signaling inhibition. As expected, after intra-tumoral injection at a 0.45 mg/kg TPL-equivalent dose three times over 14 days in 4T1 tumor-bearing mice, TPL@nano-gel led to lower systemic toxicity and higher antitumor efficacy compared to multiple injections of TPL. In this regard, these findings indicate that this injectable thermo-responsive hydrogel carries great potential for TPL as a safe and effective cancer therapy.

Triptolide (TPL) was purchased from Chengdu DeSiTe Biological Technology Co., Ltd. (Chengdu, China).

上一篇：Neurochemical Research-14 May 2020 羥基紅花黃色素A 78281-02-4

下一篇：Molecules-13 December 2019 黃連堿表小檗堿