欧美乱妇日本无乱码特黄大片,久久99精品九九九久久婷婷,日韩久久无码免费毛片软件

狠狠综合久久久久综合网,亚州少妇无套内射激情视频,成年免费A级毛片免费看丶,欧美熟妇色ⅩXXX欧美妇

鄭重說明:

您值得信賴的中藥成分及標(biāo)準(zhǔn)合作伙伴滿足您研發(fā)和工業(yè)化需求

產(chǎn)品關(guān)鍵詞：香草酸-4-β-D-葡萄糖苷 6-甲氧基山奈酚茯苓新酸B 去甲異波爾定

guanyuwomen關(guān)于德思特

聯(lián)系方式

服務(wù)熱線：

028-8500-3950

公司傳真：	028-85589956
公司郵箱：	sales@tcmlmt.com
公司網(wǎng)址：	usemark.cn
公司地址：	四川省成都市溫江區(qū)?？坡肺鞫?28號5棟

發(fā)表文獻展示

當(dāng)前位置:首頁關(guān)于德思特 > 發(fā)表文獻展示 >

6-Gingerol Alleviates Neonatal Hypoxic-Ischemic Cerebral ...

時間：2022-05-30 瀏覽次數(shù)：分享到：

Hypoxic-ischemic encephalopathy (HIE) is one main cause of neonatal death and disability,causing substantial injury to white and gray matter, which can lead to severe neurobehavioral dysfunction, including intellectual disability and dyskinesia.Inflammation, nerve cell death, and white matter injury are important factors in the pathological process of HIE. 6-Gingerol is a ginger extract, which reduces inflammatory response and cell death. However, the role of 6-Gingerol in neonatal hypoxic-ischemic brain injury (HIBI) remains unknown. In this study, we constructed a mouse HIBI model and analyzed the protective effect of 6-Gingerol on HIBI by using behavioral tests, histological staining, qPCR and western blot. Here, we found that 6-Gingerol treatment could alleviate HIBI and improve short-term reflex performance, which is closely related to cell death and neuroinflammation. Additionally, 6-Gingerol reduced neuronal apoptosis, pro-inflammatory factor release, as well as microglial activation. Furthermore, 6-Gingerol significantly improved motor disability, which is associated with white matter damage. Thus, our results showed that 6-Gingerol could reduce the loss of myelin sheaths, alleviate cell death of oligodendrocytes, and stimulate the maturation of oligodendrocytes. In terms of mechanism, we found that 6-Gingerol decreased histone H3K27me3 levels, activated AKT pathway and inhibited the activation of ERK and NF-κB pathway at 3 days post-HIBI. Taken together, our data clearly indicate that 6-Gingerol plays a neuroprotective role against HIBI by epigenetic modification and regulation of AKT, ERK, and NF-κB pathways, inhibiting inflammatory responses and reducing cell death.

......

MATERIALS AND METHODS

HIBI Model and Drugs Administration

...

6-Gingerol (DESITE, Chengdu, China) ...

上一篇：Discovery of minor quality evaluation marker ....

下一篇：Comparative bioactivity evaluation and chemical profiling...